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7 T Human MRI System
Analytical ServiceLast update : 2017.08.24
RI Category
Analytical Facilities
Keywords
7T,MRI,high field,high resolution,parallel transmission
Description
State-of-the-art Philips MRI scanner equipped with 32-channel brain array and actively-shielded superconducting magnet.
Ultra high field 7 T human MRI system can provide ultra high resolution (~0.2 mm) images, comparable to usual 1.5 T or 3 T MRI system. Many collaborators can join the studies on the brain/body functions and anatomic structures to solve the national agenda.
- Actively shielded compact 7 Tesla superconducting magnet
- Actively shielded gradient and 8 channel transmit and 32 channel receive RF systems
- Ultra-high resolution images and high resolution spectroscopic analysis
- Multi-nuclear (13C, 23Na and 31P) imaging and spectroscopic analysis
Application Area
- Studies on brain structure/brain diseases/brain functions, Diagnosis of diseases
- Studies on various body-parts (eg. abdominal region, spine, knee, foot, etc.)
Specifications
1. 7 T Human MRI
- Superconducting magnet: Actively shielded, Field strength 7.0 Tesla
- Gradient system: Amplitude 40mT/m (x, y, z, each), max. slew rate 200mT/m/msec
- RF System: 8 transmit channels, 1H amp max. power 16 kW (2 kW x 8), 32 receiver channels
- Various RF coils: 32 channel brain coil, knee coil, wrist coil, 23Na/31P/13C double tuned head coil

Publication

Jahanizadeh S, Yazdian F, Marjani A, Omidi M, Rashedi H. Int J Biol Macromol. 2017 Jul 23. pii: S0141-8130(17)32039-1. doi: 10.1016/j.ijbiomac.2017.07.101

A novel bio nanocomposite of Carboxymethyl Starch (CMS)-Chitosan (CS)-Montmorillonite (MMT) was developed for Curcumin delivery. To improve Curcumin entrapment into Cs-CMS-MMT, different ratios of Chitosan (Cs), Carboxymethyl Starch (CMS) and MMT were used. Particle size and Curcumin entrapment efficiency (EE) were highly affected by different formulation variables. Polysaccharide concentration, Cs-CMS ratio and sonication time had significant effect on particle size. MMT addition enhanced the entrapment efficiency. To optimize entrapment efficiency of Curcumin, statistical analysis was used, and an experiment based on screening design performed with two variants. Morphology and structural characterization of nanocomposite and Curcumin entrapment efficiency were analyzed. The optimal formulation had the average particles size of 35.9nm with Curcumin entrapment efficiency of 91%. Finally, the antibacterial activity of bio nanocomposite against Streptococcus mutans was assessed. Curcumin-loaded bio nanocomposite hindered the formation of biofilm on dental models very effectively.